The researchers exchanged glances, nods rippling through the group as realizations dawned. Dr Chen leaned forward, her glasses slipping slightly down her nose. "Dr Devon, on the nanoparticle vector, how would you recommend stabilizing it to avoid an immune flare-up? We've hit walls with aggregation in our simulations."
Devon met her gaze, his response flowing seamlessly, as if the answer had been waiting on the tip of his tongue. "Encapsulate in a PEGylated lipid bilayer, it's biocompatible and dodges macrophage detection effectively. Tune the zeta potential to -15 to -25 mV for that sweet spot between stability and cellular adhesion. Run a quick in vitro assay to confirm, but it should cut your aggregation issues by half."
Raj jumped in next, his voice eager. "But what about long-term degradation in vivo? Our prototypes break down unevenly after 48 hours." Devon nodded, appreciating the probe.
