Cody Christian as Jordan Reyes
Jessica Alba as Monica Reyes
Tom Holland as Peter Parker
Cole Sproude as Harry Osborn
Hunter Parrish as Flash Thompson
Sophie Turner as Gwen Stacy
Madelaine Petsch as Mary Jane Watson
Maia Mitchell as Liz Allen
Emily Rudd as Felicia Hardy
Richard Armitage as George Stacy
Karen Fukuhara as Yuri Watanabe
Lucas Till as Johnny Storm
Bobby Cannavale as Ben Grimm
David Tennant as Reed Richards
Jodie Comer as Sue Storm
Robert Patterson as Matt Murdock
William Defoe as Norman Osborn
John Cena as Sandman
Paul Sparks as Vulture
Aaron Paul as Shocker
Dave Bautista as Rhino
Richard Madden as Taskmaster
Toby Leonard Moore as James Westley
Vincent D'Onofrio as Kingpin