King Kong offered to buy the nicillin strain from Fleming. Fleming said, "No, no need to buy. I'll give it to you." Not only to King Kong, but to everyone who asked him for the strain, Fleming gave it away.
You Easterners are really amazing. Last year there was a Japanese doctor named Tanaka Sonomo who somehow knew about my penicillin strain and wanted to buy it from me, hahaha, just like you. Of course there was no need to buy it. I gave it to him.
A few days ago, Tanaka wrote to me saying that a Noda Co., Ltd. had been established and was capable of producing penicilline, but the output was still very small, much less than that of your cephalosporin. It can only be said to be laboratory-scale production, but a few times higher than the output of our laboratory.
You Easterners are amazing!
It turns out that there is no patent for the discovery of penicillin in this time and space. It was only later that some production techniques were patented.
King Kong's Pioneer mycin and its production process technology could have been patented at that time, but he did not want the technology to be leaked and did not intend to do so. Some production techniques that can be kept confidential are often better left unpatented, otherwise they are likely to be mastered by others. Except if you want to sell the technology.
European scientists such as Fleming have tested penicilline and King Kong's cephaloamycin and found that their chemical structures are different.
Science knows no borders. Invention is not for making money, but for saving the sick, for the development of civilization! Does Dr. Xu ask for patent fees for his surgical skills?
Fleming also asked King Kong if cephalosporin and his penicilline were similar drugs?
Yes, they are indeed similar.
The price that Dr. Xu is selling is really cheap! In Europe, penicilline is now much more expensive than Vajra! It's not available yet. It's only possible to buy a little for academic research, but the average patient simply can't afford it! Dr. Xu is truly a life-saving man!
Now in Europe, it's time to arrange the sales of Koyi products there. King Kong found an agent. During the medical conference, there are also a large number of pharmaceutical dealers. They had long noses, vying to act as agents for Koyi's Xianfeng Mycin. King Kong added chemical products and other Koyi products as well.
Xianfeng Mycin is still attractive, and the other products of Keyi are not bad either. So, he settled the agency rights in major European countries and even in the Americas.
King Kong wanted to go to Germany and other countries to see if he could get some gun and artillery production technology, especially submarine production technology.
King first asked Hans if it was possible to buy some German military production technology? Buy a submarine? Hans threw him a bucket of cold water.
No way! King Kong, though, has gained a little fame in the medical field. But outside the medical field, no one would pay any attention to a great Chinese.
In fact, even his cephalexin and Fleming's penicillin were not paid much attention to at this time. A new drug, said to be expensive but effective for some diseases, that's all. It's impossible to trade this technology for a submarine or something like that.
Like King Kong, if you go to Germany, you won't find anyone related to it. If you find someone familiar with military production, you may not be able to get any questions. Instead, you are more likely to be caught as a spy.
The protagonists of other YY novels, when they arrive in Europe, are received by their heads of state. They use the penicillin production method to exchange for German submarines. Then the submarine goes to fight the Japanese! How exciting!
What kind of time and space did this King Kong travel to? Bad luck!
Submarine, it's impossible to sell him without saying a word; Even if he were willing to sell, King Kong would simply not be able to afford the price of tens of millions or hundreds of millions.
During this trip to Europe, apart from opening up sales channels for Cephamycin and purchasing some medical equipment such as X-ray machines, the only unexpected gain was the purchase of some relatively pure metals: germanium, a raw material for semiconductors.
Shortly after returning to the country, King Kong received two honorary doctorates from European medical schools.
In another time and space, Japan is very good at making use of other people's scientific and technological achievements. It seems that in this time and space, the Japanese are doing the same! Who is this Tanaka Sengo? But King Kong didn't have the energy to care.
After returning to Shanghai, King Kong put the penicillin strain he had brought into production. Thanks to the production experience and equipment of cephalexin, penicillin was soon produced in large quantities. However, since cephalosporin came out earlier and there were fewer allergic reactions, penicillin sales have always been much smaller than cephalosporin.
Chinese patent medicine factories have expanded their production scale, and King Kong emphasizes the importance of quality control. These days, without the supervision of the health bureau, there is no medical license or production license to practice medicine or produce any medicine. The quality depends on the conscience of the doctors in the pharmaceutical factory. Fortunately, the conscience of the doctors in China is okay at this time.
It was the antibiotic workshop that expanded even faster than the Chinese patent medicine factory. Antibiotics, as a specific drug for diseases such as pneumonia, are purchased by countries in Europe and the United States. Despite their high prices, they are in short supply.
Because of the booming sales, King Kong felt that the production of antibiotics was still too low. The reason for the low production is that the yield per litre of culture is too small. King Kong asked Sanfeng to constantly select strains with high antibiotic yields from the cultivated fungal seedlings and eliminate those with low yields. Several large one-cubic-meter culture tanks were made, and the equipment for separation and extraction was enlarged and increased accordingly.
The profit margin of antibiotic production is higher than that of gold mining!
Hearing that some Japanese company, Noda, could produce penicilline, King Kong deliberately set the price of the penicillin he produced a little lower than that of cephalosporin.
The two drugs have different bactericidal spectra and are mutually substitutable products. So penicillin can't be priced too low either, or the price of cephalosporin won't go up. Didn't the penicillin production in the East be low? So when the price is set high, King Kong still makes more money.
In fact, there are more people allergic to penicillin than to his cephalosporin, so it makes sense that he says cephalosporin is superior to penicillin.
But in terms of production cost, penicillin is more expensive than their cephalosporin. Because of the current low ability of Penicillium to produce antibacterial suborganisms, the content of penicilline in the culture is very low, so the separation and purification are more difficult, the yield is low and the cost is higher.
King Kong has already asked Sanfeng to do the preferred culture of the cephalosporin strain in the hope of screening out the strain with high yield. Now that they have Penicillium, let them cultivate and select the best. Their original strains are all self-cultivated, and they have some experience in this aspect of technology.
Hospitals are also expanding rapidly. Because patients are crowding into their hospitals, they have no choice but to expand. The hospital originally used a building along the street. Now the building at the back has been converted into a ward, and corridors have been added on both sides to form a courtyard. In the yard, a long wooden ramp was built, allowing wheeled hospital beds to be pushed up. This is not an invention of King Kong, but a building specifically designed for hospitals in Shanghai, all like this, without elevators. Other large hospitals have elevators in their wards, and they also have such ramps. Are they afraid of power outages?
The doctor's problem is also largely settled: The foreign doctor who came to study arrived at King Kong's hospital. They actually have better medical skills than King Kong.
But King Kong doesn't have nothing to teach. First of all, of course, what to pay attention to when reattaching a severed limb. Then there is the use of antibiotics: efficacy, indications, treatment, allergies, side effects; And the efficacy of other drugs of Koyi.
The "students" of traditional Chinese medicine are relatively few. They are all young doctors who are eager to learn and have a good foundation, and they take them directly to become doctors in the hospital. King Kong also asked these traditional Chinese medicine practitioners to study Western medicine. The combination of Chinese and Western medicine is great!
To these Western doctors, King Kong also asked Ren Zhenyu to talk about some traditional Chinese medicine, such as Yin-Yang and Five Elements, which made the foreigners' heads spin.
In fact, traditional Chinese medicine also has its scientific aspects. Traditional Chinese medicine studies the body as an organic whole. Medicine decades later proved that the internal organs and other parts are closely related. For example, liver cirrhosis can cause an enlarged spleen in the patient. Traditional Chinese medicine has long been aware of the relationship between these organs, not treating the head for a headache or the foot for a foot pain, but treating systematically. The theory of Yin and Yang and the Five Elements may not be very scientific, but there is still a lot of logic in it, and even decades later it will take precedence over Western medicine theory.
Therefore, more efforts should be made to study traditional Chinese medicine. Don't wait for foreigners to say they've figured out the ingredients of a certain Chinese medicine, what amazing effects it has, and then we'll follow up and start researching it.