As for when Mikoto will awaken her Mangekyo Sharingan, Kazuki does not know, as some people need to witness the death of someone they care about to awaken it, while others only need to be on the verge of a breakup to awaken their Mangekyo Sharingan, the disparity between people is not small.
Given Mikoto's situation, Kazuki found it difficult to guarantee what kind of stimulus she would need to awaken her Mangekyo Sharingan.
Of course, there is another path available to Mikoto, which is to not blindly pursue awakening the Mangekyo Sharingan, but instead to focus on Yin-Yang Release. As for having Mikoto learn Sage Mode, Kazuki is not considering that for now.
At this point, he couldn't help but sigh with emotion that the Senju clan indeed had an advantage over the Uchiha clan.
In the cases of Tsunade and Nawaki, as long as they repeatedly injected the nutrient solution containing Hashirama's cells, their physique would be significantly enhanced, and then practicing Sage Mode would not be difficult for them.
However, for the Uchiha, due to his Sharingan and unstable mental issues, mastering Sage Mode is extraordinarily difficult.
Kazuki found it hard to guarantee that after injecting a large amount of nutrient solution, their practice of Sage Mode would be as simple as his own. After all, he is essentially cheating.
Once Tsunade and Nawaki awaken their Sharingan, they would already have mastered Sage Mode, and even if they then awaken their Sharingan, it would not pose any difficulty for them. In this regard, Tsunade and Nawaki certainly benefited.
However, the difficulty for them to activate the Sharingan might not be any less than learning Sage Mode.
But this has nothing to do with Tsunade and Nawaki. It still requires Orochimaru and Tobirama, and perhaps Tsunade will also help with the research, while Nawaki just needs to lie back and win.
If activating the Mangekyo Sharingan necessarily involves experiencing pain, then Kazuki didn't wish for Mikoto to endure such suffering. After all, Mikoto already has the three-tomoe Sharingan, and after further injections of nutrient solution, once it no longer has much effect, he can justs use the Giant Tenseigan to help Mikoto undergo bloodline atavism.
If this allows her to reach the level of Indra, or slightly less but not by much, then their initial requirements would already be met.
"I feel like I've become much stronger. My Chakra has more than doubled, and even my physique has improved, especially in terms of strength and stamina. I feel like I could fight all day now."
After adapting to her power, Mikoto clenched her fists, unleashing all her Chakra, and couldn't help but exclaim.
She felt that her Chakra seemed to be no less than Nawaki's now.
An Uchiha with the three-tomoe Sharingan actually has quite a lot of Chakra, but compared to Nawaki, it was still quite a bit less. But with this nutrient solution injection, Mikoto's Chakra had significantly increased, and even if there were no further increases, she felt this was enough.
"It seems that the First Hokage's cell solution has far greater benefits for the Uchiha than we initially expected. Once she has completely adapted to this power, a second injection can be administered."
Orochimaru observed Mikoto's condition, and with her cooperation, collected blood and cells from her, unable to help but exclaim.
"Hmph!" Tobirama let out a soft snort.
He had seen this and knew that these things absolutely could not be obtained by other Uchiha. Otherwise, no one knew what kind of trouble they would cause.
After all, the stronger an Uchiha, the more extreme their personality, with Kazuki being the exception.
After several years of interaction, Tobirama felt that Kazuki was very similar to himself.
How could a person with such a personality be insane?
(Kazuki: Tobirama, don't you think you are too extreme and insane? Moreover, your eyes are red. If you had Uchiha cells, you would activate the Mangekyo Sharingan in a minute, wouldn't you?)
"Next, it's your turn, Nawaki, Kushina." Orochimaru then turned his gaze to Kushina and Nawaki.
Both are descendants of Asura, so injecting the nutrient solution should not be very difficult. However, the effects might not be as significant as for Mikoto.
"Yes, Orochimaru-sensei, I've been waiting for this." Nawaki clenched his fists.
He and Kazuki had carried out missions in the Land of Water for a period of time, and it was precisely because they had worked together that Nawaki understood Kazuki's immense strength.
He didn't think he could catch up to Kazuki by training conventionally. With Samehada's help and his granduncle's personal guidance, Nawaki felt that in the future, he would at most grow to the level of the Third Hokage, and that would be his limit. Therefore, cheating became very necessary.
It wasn't that Nawaki lacked perseverance. He just didn't want to be left too far behind by his good friend. Only by getting stronger did he increasingly understand how big the gap was between himself and Kazuki.
Even though he was already considered an outstanding talent among the new generation, he still felt unwilling.
No matter what, he couldn't be left far behind by Kushina, could he?
"Alright."
Orochimaru gestured for Nawaki and Kushina to sit down, and then injected both of them with the nutrient solution.
He then carefully observed their conditions. Unlike Mikoto earlier, Nawaki and Kushina did not show the same repulsive reaction after the injection of the nutrient solution. Instead, it integrated smoothly and subtly, like water seeping into the ground. Both of their Chakra levels increased, but not as dramatically as Mikoto's.
This was also related to the fact that both of them originally possessed the so-called Sage Body, but the nutrient solution could still help them raise their physical limits.
Orochimaru was not disappointed by this, it was already a good start.
Their experiments were not just simple cell transplants. Instead, it was about cell fusion, activating the corresponding genes within the human body, and simultaneously completing the cells.
Orochimaru was enjoying it, even if it meant he had been deeply immersed in research for over three years, almost day and night, conducting various studies.