Leo Howard as Nathan Drake
Cillian Murphy as Richard Drake
Rebecca Hall as Cassandra Drake
Tom Holland as Peter Parker
Tye Sheridan as Harry Osborn
Dacre Montgomery as Flash Thompson
Sophie Turner as Mary Jane Watson
Anya Taylor-Joy as Gwen Stacy
Boyd Holbrook as Scorpion
Anthony Ramos as Shocker
Jason Isaacs as Norman Osborn
Samuel L Jackson as Nick Fury